GPS1 and CUL2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		GPS1	CUL2
Description		G protein pathway suppressor 1	cullin 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Inactivation Of MAPK Activity Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair JNK Cascade Negative Regulation Of GTPase Activity Post-translational Protein Modification	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		29 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 ELOB IP6K1 ITPK1 RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	25 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC GPS1 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 VHL ZER1 ZYG11B
Entrez ID		2873	8453
HPRD ID		15991	06786
Ensembl ID		ENSG00000169727	ENSG00000108094
Uniprot IDs		A0A096LP07 A0A096LPJ3 C9JFE4 Q13098	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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