CUL2 and SENP8

Data Source:
BioGRID (enzymatic study)

		CUL2	SENP8
Description		cullin 2	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Protein Deubiquitination Post-translational Protein Modification
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation	UCH proteinases Neddylation
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		25 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC GPS1 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 VHL ZER1 ZYG11B	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		8453	123228
HPRD ID		06786	09784
Ensembl ID		ENSG00000108094	ENSG00000166192
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617	A8K8D3 Q96LD8
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
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