TRIM59 and PPM1L

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)

		TRIM59	PPM1L
Description		tripartite motif containing 59	protein phosphatase, Mg2+/Mn2+ dependent 1L
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B	Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	MAPK Cascade Protein Dephosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Kawasaki disease ( 22446961) Malaria ( 31844061) Metabolite levels ( 23823483) Morning person ( 30696823) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Response to methotrexate in rheumatoid arthritis ( 24583629)
Interacting Genes		26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	3 interacting genes: EPHA2 MAP3K7 PDGFRB
Entrez ID		286827	151742
HPRD ID		15568	17889
Ensembl ID		ENSG00000213186	ENSG00000163590
Uniprot IDs		Q8IWR1	Q5SGD2
PDB IDs
Enriched GO Terms of Interacting Partners?
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