PPM1L and PDGFRB

Data Source:
BioGRID (two hybrid)

		PPM1L	PDGFRB
Description		protein phosphatase, Mg2+/Mn2+ dependent 1L	platelet derived growth factor receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Exosome	Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding
	Biological Process	MAPK Cascade Protein Dephosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sphingolipid Biosynthetic Process	MAPK Cascade Glycosaminoglycan Biosynthetic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Kinase Activity Response To Fluid Shear Stress Positive Regulation Of Rho Protein Signal Transduction Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Positive Regulation Of Chemotaxis Positive Regulation Of Protein Kinase B Signaling Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Lung Growth Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of DNA Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib
Diseases			Glioma
GWAS		Kawasaki disease ( 22446961) Malaria ( 31844061) Metabolite levels ( 23823483) Morning person ( 30696823) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Response to methotrexate in rheumatoid arthritis ( 24583629)	Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		3 interacting genes: EPHA2 MAP3K7 PDGFRB	76 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CEP76 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SLC9A3R1 SLC9A3R2 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TYK2 VAV1 YES1
Entrez ID		151742	5159
HPRD ID		17889	01423
Ensembl ID		ENSG00000163590	ENSG00000113721
Uniprot IDs		Q5SGD2	P09619 Q59F04
PDB IDs			1GQ5 1H9O 1LWP 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?
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