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APH1A and TMEM140
Data Source:
BioGRID
(two hybrid)
APH1A
TMEM140
Description
aph-1 homolog A, gamma-secretase subunit
transmembrane protein 140
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Endosome Membrane
Membrane
Integral Component Of Membrane
Golgi Cisterna Membrane
Gamma-secretase Complex
Integral Component Of Presynaptic Membrane
Integral Component Of Membrane
Molecular Function
Protein Binding
Enzyme Binding
Protein-macromolecule Adaptor Activity
Endopeptidase Activator Activity
Protein Binding
Biological Process
Metanephros Development
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Positive Regulation Of Endopeptidase Activity
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Cellular Protein Metabolic Process
Ephrin Receptor Signaling Pathway
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation
Drugs
E-2012
Diseases
GWAS
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
26955885
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Morning vs. evening chronotype (
26955885
26835600
)
Refractive error (
32231278
)
Schizophrenia (
25056061
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
36 interacting genes:
ANKRD46
APOD
ASGR1
ATF4
BHLHE40
CREB3
DRD2
FIS1
FXYD6
GLP1R
GPATCH8
GPR35
HES1
HIVEP1
IGFBP5
KLF11
LAT
MFSD6
MPP1
MRAP2
NCSTN
PSEN1
PSEN2
PSENEN
RBFOX2
SCAND1
SERP1
SLC38A7
SLC39A9
SMAGP
THPO
TLE1
TMED10
TMEM140
TMEM218
TRARG1
50 interacting genes:
APH1A
AQP6
ASGR2
CD22
CD53
CD79A
CGRRF1
CLDN5
CLDN7
CLEC17A
CLRN1
CREB3
EBP
FAM209A
FAM210B
FCER1G
FNDC9
GOLM1
GPR152
GPR42
HHLA2
HSD17B13
IFNGR2
KCNJ8
KRTAP10-8
LMNA
LY6E
MFF
MGST3
MILR1
MS4A3
MSMO1
PDZK1IP1
PSCA
RMDN3
SCN3B
SHISAL1
SIT1
SLC39A9
SPACA1
STOM
SYNE4
TEX29
TMEM182
TMEM205
TMEM207
TMEM9
TMX2
TSPAN12
TSPO2
Entrez ID
51107
55281
HPRD ID
06360
07723
Ensembl ID
ENSG00000117362
ENSG00000146859
Uniprot IDs
B4DUG7
Q96BI3
Q9NV12
PDB IDs
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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