Description |
RANBP2-type and C3HC4-type zinc finger containing 1 |
mitogen-activated protein kinase kinase kinase 1 |
Image |
|
|
Cellular Component |
|
|
Molecular Function |
|
|
Biological Process |
|
|
Pathways |
|
|
Drugs |
|
|
Diseases |
|
|
GWAS |
|
- Alanine transaminase levels ( 29403010)
- Blond vs. brown/black hair color ( 30531825)
- Brain morphology (MOSTest) ( 32665545)
- Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030)
- Breast cancer (early onset) ( 24493630)
- Brown vs. black hair color ( 30531825)
- Coronary artery disease ( 29212778)
- Cortical surface area (MOSTest) ( 32665545)
- Fasting blood insulin ( 25631608)
- Fasting glucose in pregnancy (gestational week 14-16) ( 30324795)
- Fasting insulin (dietary factor interaction) ( 24204828)
- Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)
- Initial pursuit acceleration ( 29064472)
- Lung function (FEV1) ( 30061609)
- Refractive error ( 32231278)
- Sexual dimorphism in anthropometric traits ( 23754948)
- Subcortical volume (MOSTest) ( 32665545)
- Triglyceride levels ( 28334899)
- Triglycerides ( 24097068 20686565)
- Type 2 diabetes ( 23209189)
- Urate levels (BMI interaction) ( 25811787)
- Waist circumference ( 23966867)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in active individuals ( 28448500)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412 28448500)
- Waist-hip ratio ( 25673412)
- Waist-to-hip ratio adjusted for BMI ( 26426971)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
- Youthful appearance (self-reported) ( 32339537)
|
Interacting Genes |
65 interacting genes:
APP
ARNT2
BACH1
CREB5
CREBBP
ENKD1
GLYCTK
HGS
HOXA1
HOXC8
IL16
IREB2
KANK2
LNX1
MALT1
MAP3K1
MAPKBP1
MKRN2
NAA10
NDUFAF3
NEDD4
NR1I2
OTUB2
OTUD6A
PAN2
PCGF2
PRKCA
PRKN
PSMA1
PSMD4
RNF181
RNF31
SMURF1
SOCS6
SYCE1
TNFAIP3
TP53
TRAF1
TRIM21
TRIM25
TRIM65
TRIML1
TSSK3
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2G1
UBE2K
UBE2L3
UBE2L6
UBE2N
UBE2S
UBE2U
UCHL5
UHRF2
USP15
USP2
USP21
USP32
USP49
USP7
ZNF414
|
95 interacting genes:
ACTN1
APEX2
APPL1
ARHGAP4
ASCC2
ATXN3
BAALC
BAP1
BRCA1
CARD14
CCDC69
CD74
CEP85
CHRM5
CHUK
COPS6
CRELD1
CRTC1
CUEDC1
DCUN1D1
DCUN1D2
DENND6B
DNAJB2
DNAJB6
DTX1
EPHA1
EPN1
FAF2
FAM184A
FKBP6
GGA2
GRIPAP1
GSK3B
HBS1L
HGS
HIP1
IKBKB
ILRUN
IMPACT
KRT36
MAP2K4
MAP2K7
MAPK1
MAPK9
MBP
MINDY3
NEK10
NFKBIA
NOTCH1
NPLOC4
NR4A1
ODF2
PAK1
PLEKHB2
PSMD4
RAB3IL1
RABEP2
RAD18
RAD23A
RAD51AP1
RAF1
RBCK1
RNF114
RNF126
RNF141
SPART
STAM
STAM2
TAB1
TNIP1
TOM1
TOM1L2
TP53
UBAC1
UBAP1
UBASH3B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2G1
UBE2I
UBE2K
UBE2L6
UBE2V1
UBE2W
UBQLN1
UBXN7
UCHL5
UFD1
USP28
YWHAE
ZFAND3
ZFAND5
|
Entrez ID |
10616 |
4214 |
HPRD ID |
16643 |
19599 |
Ensembl ID |
ENSG00000125826
|
ENSG00000095015
|
Uniprot IDs |
A6PVJ6
A6PVK0
Q9BYM8
|
Q13233
|
PDB IDs |
2CRC
2LGY
4DBG
|
6WHB
|
Enriched GO Terms of Interacting Partners? |
|
|
Tagcloud ? |
|
|
Tagcloud (Difference) ? |
|
|
Tagcloud (Intersection) ? |
|