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AGO2 and BTRC
Data Source:
BioGRID
(unspecified method)
AGO2
BTRC
Description
argonaute RISC catalytic component 2
beta-transducin repeat containing E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Polysome
MRNA Cap Binding Complex
Membrane
RISC Complex
Dendrite
Cytoplasmic Ribonucleoprotein Granule
Extracellular Exosome
RISC-loading Complex
Ribonucleoprotein Complex
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Molecular Function
RNA 7-methylguanosine Cap Binding
RNA Polymerase II Complex Binding
Core Promoter Sequence-specific DNA Binding
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Translation Initiation Factor Activity
Endoribonuclease Activity
Protein Binding
Protein C-terminus Binding
SiRNA Binding
MiRNA Binding
Metal Ion Binding
Endoribonuclease Activity, Cleaving SiRNA-paired MRNA
Endoribonuclease Activity, Cleaving MiRNA-paired MRNA
MRNA Cap Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Ligase Activity
Protein Phosphorylated Amino Acid Binding
Protein Dimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Translation
Translational Initiation
Wnt Signaling Pathway, Calcium Modulating Pathway
Post-embryonic Development
RNA Secondary Structure Unwinding
MiRNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Production Of SiRNA Involved In RNA Interference
Gene Silencing By RNA
Pre-miRNA Processing
SiRNA Loading Onto RISC Involved In RNA Interference
Post-transcriptional Gene Silencing By RNA
Production Of MiRNAs Involved In Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
MRNA Cleavage Involved In Gene Silencing By MiRNA
MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA
Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Translational Initiation
Positive Regulation Of Translation, NcRNA-mediated
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Regulation Of Gene Silencing By MiRNA
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
MRNA Cleavage Involved In Gene Silencing By SiRNA
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Positive Regulation Of Trophoblast Cell Migration
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Mammary Gland Epithelial Cell Proliferation
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Positive Regulation Of Proteolysis
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Rhythmic Process
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Cellular Response To Organic Cyclic Compound
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Transcriptional Regulation by MECP2
Transcriptional Regulation by MECP2
Estrogen-dependent gene expression
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neurociticism (
29500382
)
Diastolic blood pressure (
30224653
)
Red blood cell count (
29403010
)
Red cell distribution width (
32888494
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
23 interacting genes:
AGO1
BTRC
DCP1A
DCP2
DDX20
DHX58
DICER1
GEMIN4
KAT5
MAPKAPK2
MIR19A
MIRLET7B
MIRLET7I
NSD2
PFKP
PRKRA
RAD51
TARBP2
TBK1
TBKBP1
TRIM55
TRIM63
UBC
82 interacting genes:
AGO2
AMER1
ATF4
AXIN1
AXIN2
BORA
CCND1
CCNE1
CDC25A
CDC34
CDK1
CENPW
CHPF
CHUK
CP
CTNNB1
CUL1
DBN1
DEPTOR
DLGAP5
E2F1
FBXW11
FBXW2
FOXO3
FZR1
GHR
GLI2
GLI3
GSK3B
HIPK2
HNRNPC
HNRNPK
HNRNPU
ICE1
IL10RA
JUP
KDR
KMT5A
LPCAT1
MCL1
MDM2
MYB
MYC
NFE2
NFKB1
NFKB2
NFKBIA
NFKBIB
NHSL2
PAQR3
PCDH8
PDCD4
PER2
PLK4
PRDX1
PSMA3
PSMD4
RASSF5
RCAN1
RELA
RNF7
SKP1
SMAD3
SMAD4
SMURF1
SMURF2
SUFU
TACC1
TAZ
TIAM1
TP63
TRIB2
TRIM36
TRIM9
TSPAN15
UBC
UBE2D2
UBE2R2
UBQLN2
WEE1
XRCC1
ZC3H12A
Entrez ID
27161
8945
HPRD ID
06943
04596
Ensembl ID
ENSG00000123908
ENSG00000166167
Uniprot IDs
Q9UKV8
A0A0S2Z4P6
B2R8L3
B7Z3H4
Q68DS0
Q9Y297
PDB IDs
3LUC
3LUD
3LUG
3LUH
3LUJ
3LUK
3QX8
3QX9
4F3T
4OLA
4OLB
4W5N
4W5O
4W5Q
4W5R
4W5T
4Z4C
4Z4D
4Z4E
4Z4F
4Z4G
4Z4H
4Z4I
5JS1
5JS2
5KI6
5T7B
5WEA
6CBD
6MDZ
6MFN
6MFR
6N4O
6NIT
6RA4
1P22
2P64
6M90
6M91
6M92
6M93
6M94
6TTU
Enriched GO Terms of Interacting Partners
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