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AGO2 and GEMIN4
Data Source:
BioGRID
(pull down, affinity chromatography technology)
AGO2
GEMIN4
Description
argonaute RISC catalytic component 2
gem nuclear organelle associated protein 4
Image
No pdb structure
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Polysome
MRNA Cap Binding Complex
Membrane
RISC Complex
Dendrite
Cytoplasmic Ribonucleoprotein Granule
Extracellular Exosome
RISC-loading Complex
Ribonucleoprotein Complex
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cajal Body
Membrane
Nuclear Body
Small Nuclear Ribonucleoprotein Complex
SMN Complex
SMN-Sm Protein Complex
Extracellular Exosome
Gemini Of Coiled Bodies
Molecular Function
RNA 7-methylguanosine Cap Binding
RNA Polymerase II Complex Binding
Core Promoter Sequence-specific DNA Binding
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Translation Initiation Factor Activity
Endoribonuclease Activity
Protein Binding
Protein C-terminus Binding
SiRNA Binding
MiRNA Binding
Metal Ion Binding
Endoribonuclease Activity, Cleaving SiRNA-paired MRNA
Endoribonuclease Activity, Cleaving MiRNA-paired MRNA
MRNA Cap Binding
Protein Binding
Ribonucleoprotein Complex Binding
Biological Process
Translation
Translational Initiation
Wnt Signaling Pathway, Calcium Modulating Pathway
Post-embryonic Development
RNA Secondary Structure Unwinding
MiRNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Production Of SiRNA Involved In RNA Interference
Gene Silencing By RNA
Pre-miRNA Processing
SiRNA Loading Onto RISC Involved In RNA Interference
Post-transcriptional Gene Silencing By RNA
Production Of MiRNAs Involved In Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
MRNA Cleavage Involved In Gene Silencing By MiRNA
MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA
Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Translational Initiation
Positive Regulation Of Translation, NcRNA-mediated
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Regulation Of Gene Silencing By MiRNA
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
MRNA Cleavage Involved In Gene Silencing By SiRNA
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Positive Regulation Of Trophoblast Cell Migration
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Spliceosomal SnRNP Assembly
RRNA Processing
Import Into Nucleus
Pathways
Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Transcriptional Regulation by MECP2
Transcriptional Regulation by MECP2
Estrogen-dependent gene expression
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
snRNP Assembly
Drugs
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neurociticism (
29500382
)
Prostate cancer (
23535732
)
Interacting Genes
23 interacting genes:
AGO1
BTRC
DCP1A
DCP2
DDX20
DHX58
DICER1
GEMIN4
KAT5
MAPKAPK2
MIR19A
MIRLET7B
MIRLET7I
NSD2
PFKP
PRKRA
RAD51
TARBP2
TBK1
TBKBP1
TRIM55
TRIM63
UBC
55 interacting genes:
AGO2
ALPP
CALCOCO2
CCDC185
CCT3
CDC20B
CERCAM
CFP
DDX20
DHX9
DMPK
FBXL12
FLAD1
GEMIN5
GLYR1
HR
KANK2
KARS1
KRTAP13-2
KRTAP13-4
KRTAP15-1
KRTAP2-3
KRTAP2-4
KRTAP9-2
LGALS1
LGALS3
LY86
MORC4
NPPB
NUFIP1
PIAS3
PSMB1
PTCD1
PTEN
RAD51D
RN7SL1
RNU1-1
RNU2-1
S1PR4
SNRPB
SNRPD1
SNRPD2
SPG21
SPRY1
SQSTM1
SRRT
STXBP2
STXBP3
TAP1
TOP1
UFC1
USP15
USP2
ZNF326
ZNF35
Entrez ID
27161
50628
HPRD ID
06943
07370
Ensembl ID
ENSG00000123908
ENSG00000179409
Uniprot IDs
Q9UKV8
I3L2C7
P57678
Q8WUM5
PDB IDs
3LUC
3LUD
3LUG
3LUH
3LUJ
3LUK
3QX8
3QX9
4F3T
4OLA
4OLB
4W5N
4W5O
4W5Q
4W5R
4W5T
4Z4C
4Z4D
4Z4E
4Z4F
4Z4G
4Z4H
4Z4I
5JS1
5JS2
5KI6
5T7B
5WEA
6CBD
6MDZ
6MFN
6MFR
6N4O
6NIT
6RA4
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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