SMC1B and SMC3

Data Source:
HPRD (in vivo, in vitro)

		SMC1B	SMC3
Description		structural maintenance of chromosomes 1B	structural maintenance of chromosomes 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Lateral Element Nucleus Nucleoplasm Cytosol Cohesin Complex Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	DNA Binding ATP Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Meiotic Cell Cycle	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		Meiotic synapsis	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Height ( 28552196) Peanut allergy (maternal genetic effects) ( 29489655)	Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		1 interacting genes: SMC3	18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		27127	9126
HPRD ID		10564	05829
Ensembl ID		ENSG00000077935	ENSG00000108055
Uniprot IDs		Q8NDV3	Q9UQE7
PDB IDs			6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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