GJA8 and AQP4

Data Source:
BioGRID (two hybrid)

		GJA8	AQP4
Description		gap junction protein alpha 8	aquaporin 4
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Connexin Complex	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Sarcolemma Astrocyte End-foot
	Molecular Function	Gap Junction Channel Activity Protein Binding Identical Protein Binding	Protein Binding Water Channel Activity
	Biological Process	Lens Development In Camera-type Eye Cell-cell Signaling Transmembrane Transport Gap Junction-mediated Intercellular Transport	Renal Water Homeostasis Water Transport Cellular Water Homeostasis Water Homeostasis Multicellular Organismal Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Interferon-gamma Cerebrospinal Fluid Circulation
Pathways		Gap junction assembly	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS		Retinopathy x type 2 diabetes interaction ( 32541925)	Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)
Interacting Genes		121 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 YIF1A YIPF6	7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4
Entrez ID		2703	361
HPRD ID		02939	02631
Ensembl ID		ENSG00000121634	ENSG00000171885
Uniprot IDs		P48165 X5D7G1	A0A5F9ZHR4 F1DSG4 P55087 V9PBN7
PDB IDs			3GD8
Enriched GO Terms of Interacting Partners?
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