AQP4 and HPCAL4

Data Source:
BioGRID (two hybrid)

		AQP4	HPCAL4
Description		aquaporin 4	hippocalcin like 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Sarcolemma Astrocyte End-foot
	Molecular Function	Protein Binding Water Channel Activity	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Renal Water Homeostasis Water Transport Cellular Water Homeostasis Water Homeostasis Multicellular Organismal Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Interferon-gamma Cerebrospinal Fluid Circulation	Signal Transduction Central Nervous System Development
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)	Bone mineral density (Ward's triangle area) ( 27397699)
Interacting Genes		7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4	16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A
Entrez ID		361	51440
HPRD ID		02631	17113
Ensembl ID		ENSG00000171885	ENSG00000116983
Uniprot IDs		A0A5F9ZHR4 F1DSG4 P55087 V9PBN7	B4DGW9 Q9UM19
PDB IDs		3GD8
Enriched GO Terms of Interacting Partners?
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