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GJA8 and APOA2
Data Source:
BioGRID
(two hybrid)
GJA8
APOA2
Description
gap junction protein alpha 8
apolipoprotein A2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Plasma Membrane
Connexin Complex
Extracellular Region
Early Endosome
Endoplasmic Reticulum Lumen
Cytosol
Very-low-density Lipoprotein Particle
High-density Lipoprotein Particle
Spherical High-density Lipoprotein Particle
Chylomicron
Extracellular Exosome
Blood Microparticle
Molecular Function
Gap Junction Channel Activity
Protein Binding
Identical Protein Binding
Signaling Receptor Binding
Lipid Transporter Activity
Protein Binding
Phospholipid Binding
High-density Lipoprotein Particle Binding
Lipid Binding
Cholesterol Binding
Heat Shock Protein Binding
Phosphatidylcholine Binding
Apolipoprotein Receptor Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Lipase Inhibitor Activity
Phosphatidylcholine-sterol O-acyltransferase Activator Activity
High-density Lipoprotein Particle Receptor Binding
Cholesterol Transfer Activity
Biological Process
Lens Development In Camera-type Eye
Cell-cell Signaling
Transmembrane Transport
Gap Junction-mediated Intercellular Transport
Retinoid Metabolic Process
Negative Regulation Of Cytokine Production Involved In Immune Response
Triglyceride Metabolic Process
Phosphatidylcholine Biosynthetic Process
Cholesterol Metabolic Process
Phospholipid Catabolic Process
Response To Glucose
Positive Regulation Of Cholesterol Esterification
Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling
Viral Process
Protein Oxidation
Peptidyl-methionine Modification
Regulation Of Lipid Metabolic Process
Cholesterol Transport
Regulation Of Protein Stability
Negative Regulation Of Cholesterol Transport
Positive Regulation Of Interleukin-8 Production
Cholesterol Efflux
Phospholipid Efflux
Triglyceride-rich Lipoprotein Particle Remodeling
Chylomicron Remodeling
Low-density Lipoprotein Particle Remodeling
High-density Lipoprotein Particle Remodeling
Chylomicron Assembly
High-density Lipoprotein Particle Assembly
High-density Lipoprotein Particle Clearance
Lipoprotein Metabolic Process
Cholesterol Homeostasis
Post-translational Protein Modification
Reverse Cholesterol Transport
Cellular Protein Metabolic Process
Diacylglycerol Catabolic Process
Positive Regulation Of Phagocytosis
Protein Stabilization
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Lipid Catabolic Process
Negative Regulation Of Lipase Activity
Negative Regulation Of Cholesterol Import
Negative Regulation Of Cholesterol Transporter Activity
Intermembrane Lipid Transfer
Pathways
Gap junction assembly
PPARA activates gene expression
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
Chylomicron remodeling
Retinoid metabolism and transport
Retinoid metabolism and transport
Drugs
Zinc
Copper
Zinc acetate
Diseases
Familial amyloidosis
GWAS
Retinopathy x type 2 diabetes interaction (
32541925
)
Interacting Genes
121 interacting genes:
ABL1
ACKR2
APOA2
APOD
APOL3
AQP4
ARL6IP6
ATP6V0B
C1GALT1
C2CD2L
C3orf52
CCDC167
CCL4
CD53
CIAO2A
CLDN19
CLDN4
CLEC1A
CLN6
COX20
CTXN3
CXCL16
CYBC1
CYP4F2
DEFB121
DOLK
ERMP1
FDFT1
FXYD6
GIMAP1
GIMAP5
GJB2
GPR108
GPR151
GPR61
GUCA2A
IGFBP5
INSIG2
ITGAM
KIR2DL3
LAPTM4B
LAT
LEPROTL1
LHFPL5
MAL
MALL
MARCHF2
MFSD11
MFSD6
MGST2
MIP
MS4A13
ORMDL2
OTOP2
P2RY13
PGAP2
PLN
PMP22
PNLIPRP1
PRAF2
PROKR2
PTPRN
QRFPR
REEP6
RNF152
RUSF1
RXFP4
S1PR5
SCARF1
SEC22B
SEC22C
SEC23A
SFTPC
SLC13A2
SLC13A5
SLC16A12
SLC16A13
SLC16A3
SLC30A3
SLC35A4
SLC35F1
SLC35F6
SLC38A4
SLC38A7
SLC39A2
SLC39A7
SLC39A9
SLC52A1
SLC66A1
SLC66A2
SLC8A3
SMCO4
SMIM1
STX1B
STX8
THSD7B
TJP1
TMBIM6
TMEM100
TMEM107
TMEM121
TMEM128
TMEM147
TMEM182
TMEM239
TMEM242
TMEM243
TMEM42
TMEM45A
TMEM60
TMEM65
TMEM72
TMEM86B
TSPAN33
TWSG1
UBXN8
UNC93A
UPK1B
VAMP5
YIF1A
YIPF6
31 interacting genes:
ABCA13
APOA1
APOC1
APOD
APOF
AQP6
C4A
CATSPER1
CIAO2A
CREB3
CYBC1
GET1
GJA8
HSD17B13
KIR2DL3
LMNA
MUC1
NAXE
NDRG1
PANX1
PDZK1IP1
PLTP
PSCA
SCARB1
SLC7A1
SSMEM1
STOM
TMEM45A
TMEM82
TREM2
VKORC1
Entrez ID
2703
336
HPRD ID
02939
00129
Ensembl ID
ENSG00000121634
ENSG00000158874
Uniprot IDs
P48165
X5D7G1
P02652
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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