HAVCR1 and SEMA4A

Data Source:
HPRD (in vivo, in vitro)

		HAVCR1	SEMA4A
Description		hepatitis A virus cellular receptor 1	semaphorin 4A
Image			No pdb structure
GO Annotations	Cellular Component	Cell Surface Integral Component Of Membrane Motile Cilium	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Phagocytosis, Engulfment Positive Regulation Of Mast Cell Activation Viral Entry Into Host Cell	Angiogenesis Neural Crest Cell Migration Axon Guidance Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration T-helper 1 Cell Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Inhibitory Synapse Assembly
Pathways			Other semaphorin interactions
Drugs
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Cholesterol, total ( 25961943 20686565) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 19060906 25961943 20686565) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 29593015) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577) Total cholesterol levels ( 29403010) Triglyceride levels ( 32154731) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 25961943 20686565)	Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Stroke ( 29531354) Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: DYNLT1 SEMA4A UBQLN4	3 interacting genes: DDX54 HAVCR1 PLXND1
Entrez ID		26762	64218
HPRD ID		09404	09528
Ensembl ID		ENSG00000113249	ENSG00000196189
Uniprot IDs		B4DPB1 E9PFX0 Q96D42	B4DKS5 Q9H3S1
PDB IDs		5DZO 5F70
Enriched GO Terms of Interacting Partners?
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