SPAG8 and HR

Data Source:
BioGRID (two hybrid)

		SPAG8	HR
Description		sperm associated antigen 8	HR lysine demethylase and nuclear receptor corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane	Histone Deacetylase Complex Chromatin Nucleoplasm
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Transcription Coregulator Activity Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding
	Biological Process	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Histone H3-K9 Demethylation
Pathways
Drugs
Diseases			Atrichia with papular lesions Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH)
GWAS		Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545)	Obesity-related traits ( 23251661)
Interacting Genes		87 interacting genes: ARMC5 B9D2 BATF2 C19orf54 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581	35 interacting genes: AMMECR1 ATP23 C11orf1 C19orf54 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12
Entrez ID		26206	55806
HPRD ID		12039	03808
Ensembl ID		ENSG00000137098	ENSG00000168453
Uniprot IDs		A0A140VJV0 Q99932	O43593
PDB IDs
Enriched GO Terms of Interacting Partners?
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