KLHL3 and WNK3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method)

		KLHL3	WNK3
Description		kelch like family member 3	WNK lysine deficient protein kinase 3
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol Adherens Junction Bicellular Tight Junction
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	Protein Phosphorylation Cell Volume Homeostasis Osmosensory Signaling Pathway Positive Regulation Of Sodium Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Protein Autophosphorylation Ion Homeostasis Positive Regulation Of Calcium Ion Transport Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Stimuli-sensing channels
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Height ( 28552196)
Interacting Genes		18 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK1 WNK3 WNK4	4 interacting genes: KLHL3 LBX1 REL TSC22D2
Entrez ID		26249	65267
HPRD ID		09011	02289
Ensembl ID		ENSG00000146021	ENSG00000196632
Uniprot IDs		Q9UH77	Q9BYP7
PDB IDs		4CH9 4HXI 5NKP	5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C
Enriched GO Terms of Interacting Partners?
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