WNK3 and LBX1

Data Source:
BioGRID (two hybrid)

		WNK3	LBX1
Description		WNK lysine deficient protein kinase 3	ladybird homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Adherens Junction Bicellular Tight Junction	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Cell Volume Homeostasis Osmosensory Signaling Pathway Positive Regulation Of Sodium Ion Transport Negative Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Protein Autophosphorylation Ion Homeostasis Positive Regulation Of Calcium Ion Transport Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Heart Looping Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Negative Regulation Of Neuron Differentiation Neuron Fate Determination
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Height ( 28552196)	Adolescent idiopathic scoliosis ( 31417091 26211971 30395268) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779)
Interacting Genes		4 interacting genes: KLHL3 LBX1 REL TSC22D2	23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483
Entrez ID		65267	10660
HPRD ID		02289	09178
Ensembl ID		ENSG00000196632	ENSG00000138136
Uniprot IDs		Q9BYP7	P52954
PDB IDs		5NKP 5O1V 5O21 5O23 5O26 5O2B 5O2C
Enriched GO Terms of Interacting Partners?
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