KLHL3 and OPRD1

Data Source:
HPRD (in vivo)

		KLHL3	OPRD1
Description		kelch like family member 3	opioid receptor delta 1
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Intrinsic Component Of Plasma Membrane Dendrite Membrane Neuron Projection Axon Terminus Membrane Raft Spine Apparatus Neuronal Dense Core Vesicle Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding Enkephalin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Opioid Receptor Signaling Pathway Eating Behavior Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Tourette syndrome ( 30818990)
Interacting Genes		18 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK1 WNK3 WNK4	22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237
Entrez ID		26249	4985
HPRD ID		09011	01308
Ensembl ID		ENSG00000146021	ENSG00000116329
Uniprot IDs		Q9UH77	P41143
PDB IDs		4CH9 4HXI 5NKP	1OZC 2IQM 4N6H 4RWA 4RWD 6PT2 6PT3
Enriched GO Terms of Interacting Partners?
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