KLHL3 and MORF4L2

Data Source:
BioGRID (two hybrid)

		KLHL3	MORF4L2
Description		kelch like family member 3	mortality factor 4 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Histone Acetyltransferase Complex Nucleoplasm Nucleolus Plasma Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	DNA Repair Chromatin Silencing Histone Acetylation Histone Deacetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Striated Muscle Cell Differentiation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	HATs acetylate histones
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494)
Interacting Genes		18 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK1 WNK3 WNK4	53 interacting genes: AMOTL2 ARID3A BCL11A BEND7 BEX5 CAMK2B CDR2 CEP55 DDIT4L DISC1 EVI5 FAM9B FBXO16 GOLGA2 GPBP1 GRAMD2B HDAC1 HMBOX1 HOMEZ IKZF1 KCTD1 KLHL3 L3MBTL3 LUZP4 LZTS2 MEOX2 MRFAP1 MRFAP1L1 MRGBP MRPL12 NAB2 PHC2 PIBF1 PICK1 PNMA2 POU6F2 RB1 REL SIN3A SYN3 THAP1 TLE1 TLE5 TNIP1 TNNT2 TRIM41 TSN ZBTB10 ZBTB14 ZBTB26 ZBTB43 ZBTB7B ZNF48
Entrez ID		26249	9643
HPRD ID		09011	02326
Ensembl ID		ENSG00000146021	ENSG00000123562
Uniprot IDs		Q9UH77	Q15014
PDB IDs		4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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