KLHL3 and CUL3

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down, pull down, two hybrid)

		KLHL3	CUL3
Description		kelch like family member 3	cullin 3
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Polar Microtubule Cytosol Plasma Membrane Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Sperm Flagellum Extracellular Exosome Mitotic Spindle
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Protein Autoubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 28991256 25056061 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		18 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK1 WNK3 WNK4	78 interacting genes: ABTB1 ABTB2 ACLY APP ARHGEF12 BTBD1 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CLK1 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 ELOC FOLR1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD13 KCTD17 KCTD5 KCTD6 KCTD7 KCTD9 KEAP1 KLHL12 KLHL2 KLHL3 KLHL42 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDCD6 PDIA2 PEF1 RBBP8 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SPOP SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 UBE2R2 WNT7B ZMAT4
Entrez ID		26249	8452
HPRD ID		09011	09123
Ensembl ID		ENSG00000146021	ENSG00000036257
Uniprot IDs		Q9UH77	A0A024R475 B7Z600 Q13618
PDB IDs		4CH9 4HXI 5NKP	2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M
Enriched GO Terms of Interacting Partners?
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