FBXL3 and CRY1

Data Source:
BioGRID (enzymatic study)

		FBXL3	CRY1
Description		F-box and leucine rich repeat protein 3	cryptochrome circadian regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytosol Nuclear Body SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding E-box Binding FAD Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Post-translational Protein Modification Rhythmic Process Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis DNA Damage Induced Protein Phosphorylation Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Association of TriC/CCT with target proteins during biosynthesis Circadian Clock Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Circadian Clock
Drugs
Diseases
GWAS		Chronotype ( 30696823) Metabolite levels ( 23823483) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Morning person ( 30696823)
Interacting Genes		7 interacting genes: CDC34 CEP57 CRY1 MSRA PICK1 SKP1 UBE2D2	26 interacting genes: ARIH1 ARNTL BHLHE41 CBLB CLOCK CSNK1E DELEC1 FBXL3 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7
Entrez ID		26224	1407
HPRD ID		05737	09050
Ensembl ID		ENSG00000005812	ENSG00000008405
Uniprot IDs		Q9UKT7	A2I2P0 Q16526
PDB IDs		4I6J
Enriched GO Terms of Interacting Partners?
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