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CRY1 and PPP2R5E
Data Source:
BioGRID
(two hybrid)
CRY1
PPP2R5E
Description
cryptochrome circadian regulator 1
protein phosphatase 2 regulatory subunit B'epsilon
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Protein Phosphatase Type 2A Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
DNA Binding
Double-stranded DNA Binding
Deoxyribodipyrimidine Photo-lyase Activity
DNA (6-4) Photolyase Activity
Protein Binding
Blue Light Photoreceptor Activity
Protein Kinase Binding
Phosphatase Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
E-box Binding
FAD Binding
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Gluconeogenesis
DNA Damage Induced Protein Phosphorylation
Circadian Rhythm
Response To Light Stimulus
Blue Light Signaling Pathway
Response To Activity
Protein-chromophore Linkage
Lipid Storage
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Glucagon
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Gluconeogenesis
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Glucocorticoid Secretion
Protein Dephosphorylation
Signal Transduction
Regulation Of Protein Autophosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Circadian Clock
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Morning person (
30696823
)
Low density lipoprotein cholesterol levels (
32154731
)
Response to antineoplastic agents (
21659360
)
Systolic blood pressure (
28135244
)
Triglyceride levels (
32154731
)
Interacting Genes
26 interacting genes:
ARIH1
ARNTL
BHLHE41
CBLB
CLOCK
CSNK1E
DELEC1
FBXL3
GRN
KRTAP4-12
LTBP4
MDFI
NPAS2
NR1D2
PER1
PER2
PER3
PLSCR1
PPP2R1B
PPP2R5D
PPP2R5E
SNRPD3
TIMELESS
TRAF2
USP2
USP7
20 interacting genes:
APP
BHLHB9
BHLHE41
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DOCK9
ENO1
FBXW11
PPP1CA
PPP2CA
PPP2R1B
RACGAP1
RORC
SGO1
SMAD9
Entrez ID
1407
5529
HPRD ID
09050
09040
Ensembl ID
ENSG00000008405
ENSG00000154001
Uniprot IDs
A2I2P0
Q16526
Q16537
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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