CRY1 and FBXL3

Data Source:
BioGRID (enzymatic study)

		CRY1	FBXL3
Description		cryptochrome circadian regulator 1	F-box and leucine rich repeat protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Ubiquitin Ligase Complex Nucleus Cytosol Nuclear Body SCF Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding E-box Binding FAD Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis DNA Damage Induced Protein Phosphorylation Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Post-translational Protein Modification Rhythmic Process Regulation Of Cell Cycle
Pathways		Circadian Clock	Association of TriC/CCT with target proteins during biosynthesis Circadian Clock Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Morning person ( 30696823)	Chronotype ( 30696823) Metabolite levels ( 23823483) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		26 interacting genes: ARIH1 ARNTL BHLHE41 CBLB CLOCK CSNK1E DELEC1 FBXL3 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7	7 interacting genes: CDC34 CEP57 CRY1 MSRA PICK1 SKP1 UBE2D2
Entrez ID		1407	26224
HPRD ID		09050	05737
Ensembl ID		ENSG00000008405	ENSG00000005812
Uniprot IDs		A2I2P0 Q16526	Q9UKT7
PDB IDs			4I6J
Enriched GO Terms of Interacting Partners?
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