FBXL3 and CEP57

Data Source:
BioGRID (two hybrid)

		FBXL3	CEP57
Description		F-box and leucine rich repeat protein 3	centrosomal protein 57
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytosol Nuclear Body SCF Ubiquitin Ligase Complex	Nucleus Golgi Apparatus Centrosome Cytosol Microtubule
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Post-translational Protein Modification Rhythmic Process Regulation Of Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Anchoring Protein Homooligomerization Ciliary Basal Body-plasma Membrane Docking
Pathways		Association of TriC/CCT with target proteins during biosynthesis Circadian Clock Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Chronotype ( 30696823) Metabolite levels ( 23823483) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 30423114 24390342) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		7 interacting genes: CDC34 CEP57 CRY1 MSRA PICK1 SKP1 UBE2D2	47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 DISC1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1
Entrez ID		26224	9702
HPRD ID		05737	16261
Ensembl ID		ENSG00000005812	ENSG00000166037
Uniprot IDs		Q9UKT7	Q86XR8
PDB IDs		4I6J	4L0R
Enriched GO Terms of Interacting Partners?
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