SH2B1 and SH2B2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SH2B1	SH2B2
Description		SH2B adaptor protein 1	SH2B adaptor protein 2
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Factors involved in megakaryocyte development and platelet production	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 29381148 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)	Type 2 diabetes ( 31049640)
Interacting Genes		17 interacting genes: CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2	42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		25970	10603
HPRD ID		12336	16097
Ensembl ID		ENSG00000178188	ENSG00000160999
Uniprot IDs		A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2	O14492
PDB IDs		5W3R	1Q2H
Enriched GO Terms of Interacting Partners?
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