SH2B1 and CSAD

Data Source:
BioGRID (two hybrid)

		SH2B1	CSAD
Description		SH2B adaptor protein 1	cysteine sulfinic acid decarboxylase
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Aspartate 1-decarboxylase Activity Sulfinoalanine Decarboxylase Activity Pyridoxal Phosphate Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process	L-cysteine Catabolic Process To Hypotaurine L-cysteine Catabolic Process To Taurine Taurine Biosynthetic Process
Pathways		Factors involved in megakaryocyte development and platelet production	Degradation of cysteine and homocysteine
Drugs			Pyridoxal phosphate Cysteine
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 29381148 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)	Fulminant type 1 diabetes ( 30552108) Obesity-related traits ( 23251661)
Interacting Genes		17 interacting genes: CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2	11 interacting genes: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SH2B1 SMN1 TK1
Entrez ID		25970	51380
HPRD ID		12336	16763
Ensembl ID		ENSG00000178188	ENSG00000139631
Uniprot IDs		A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2	A0A024RAX7 Q86V02 Q96JQ3 Q9Y600
PDB IDs		5W3R	2JIS
Enriched GO Terms of Interacting Partners?
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