USP49 and MED8

Data Source:
HPRD (in vivo)

		USP49	MED8
Description		ubiquitin specific peptidase 49	mediator complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Histone H2B Conserved C-terminal Lysine Deubiquitination	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination
Pathways		Ub-specific processing proteases	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774	32 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 PRKAR1B SNTA1 THOC7 UBALD1 USP49
Entrez ID		25862	112950
HPRD ID		10075	06991
Ensembl ID		ENSG00000164663	ENSG00000159479
Uniprot IDs		Q70CQ1	Q96G25
PDB IDs
Enriched GO Terms of Interacting Partners?
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