USP49 and TRIM35

Data Source:
BioGRID (two hybrid)

		USP49	TRIM35
Description		ubiquitin specific peptidase 49	tripartite motif containing 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Histone Binding	Molecular_function Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Histone H2B Conserved C-terminal Lysine Deubiquitination	Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways		Ub-specific processing proteases	Interferon gamma signaling
Drugs
Diseases
GWAS		Cutaneous psoriasis ( 26626624) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)	Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)
Interacting Genes		12 interacting genes: FKBP5 H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774	49 interacting genes: ADIPOQ BANP CABP2 COL8A1 DTX2 ENKD1 FNDC3B GNMT HNRNPA2B1 IGFN1 KANK2 LCK LMO1 MGAT5B NRF1 PAN2 PARD6B PDCD5 PHF24 PKM PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QARS1 SHC3 SMARCB1 TCEANC TRAPPC6A TRIM10 TRIM11 TRIM5 TRIM55 TRIM63 TSG101 TSSK3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49 ZNF410
Entrez ID		25862	23087
HPRD ID		10075	15553
Ensembl ID		ENSG00000164663	ENSG00000104228
Uniprot IDs		Q70CQ1	E5RGB3 Q9UPQ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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