SMO and RPN2

Data Source:
BioGRID (two hybrid)

		SMO	RPN2
Description		smoothened, frizzled class receptor	ribophorin II
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Cilium Integral Component Of Membrane Dendrite Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium	Autophagosome Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Nuclear Body
	Molecular Function	G Protein-coupled Receptor Activity Patched Binding Protein Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Ribosome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Ventral Midline Determination Central Nervous System Development Midgut Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Population Maintenance Regulation Of Heart Morphogenesis	Cellular Protein Modification Process Protein N-linked Glycosylation Aging Protein N-linked Glycosylation Via Asparagine Response To Drug
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein
Drugs		Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases		Basal cell carcinoma
GWAS		Osteoarthritis (hip) ( 30374069)	Height ( 31562340) Hippocampal atrophy ( 19668339) Initial pursuit acceleration in psychotic disorders ( 29064472)
Interacting Genes		28 interacting genes: ARV1 C18orf32 C4orf3 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS	12 interacting genes: ADRM1 EZH2 FBN3 LTB4R2 NDRG1 NGFR PTEN RBBP4 RCHY1 RHOA SLC22A2 SMO
Entrez ID		6608	6185
HPRD ID		03294	01609
Ensembl ID		ENSG00000128602	ENSG00000118705
Uniprot IDs		Q99835	P04844
PDB IDs		4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM	6S7O 6S7T
Enriched GO Terms of Interacting Partners?
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