GAD1 and STK3

Data Source:
BioGRID (two hybrid)

		GAD1	STK3
Description		glutamate decarboxylase 1	serine/threonine kinase 3
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GO Annotations	Cellular Component	Plasma Membrane Cell Cortex Vesicle Membrane Axon Terminus Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding Protein N-terminus Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Social Behavior Locomotory Exploration Behavior Neurotransmitter Biosynthetic Process Response To Drug	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	Signaling by Hippo
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glutamic acid	Fostamatinib
Diseases		Cerebral palsy
GWAS		Menopause (age at onset) ( 26414677)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		15 interacting genes: AGTRAP CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE STK3 TRIM23 TRIP6	40 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MARK2 MBP MOB1B MOB3B MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 RASSF2 RASSF4 SAV1 SLMAP SNIP1 STK4 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		2571	6788
HPRD ID		12011	05433
Ensembl ID		ENSG00000128683	ENSG00000104375
Uniprot IDs		A0A0S2Z3V5 Q8IVA8 Q99259	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		2OKJ 3VP6	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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