GAD1 and TRIP6

Data Source:
BioGRID (two hybrid)

		GAD1	TRIP6
Description		glutamate decarboxylase 1	thyroid hormone receptor interactor 6
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GO Annotations	Cellular Component	Plasma Membrane Cell Cortex Vesicle Membrane Axon Terminus Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding Protein N-terminus Binding	RNA Binding Interleukin-1 Receptor Binding Protein Binding Kinase Binding Metal Ion Binding Thyroid Hormone Receptor Binding
	Biological Process	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Social Behavior Locomotory Exploration Behavior Neurotransmitter Biosynthetic Process Response To Drug	Signal Transduction Positive Regulation Of Cell Migration Chordate Embryonic Development Focal Adhesion Assembly Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases		Cerebral palsy
GWAS		Menopause (age at onset) ( 26414677)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Interacting Genes		15 interacting genes: AGTRAP CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE STK3 TRIM23 TRIP6	164 interacting genes: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP23 ATP5PO ATXN1 AXIN1 BAG3 BCAR1 BEX2 BYSL C11orf87 CATSPER1 CBLC CCDC120 CCDC187 CCDC24 CCL5 CEP57L1 CNTF CREB5 CRYBA4 CTAG2 DHX37 DMRT3 DTX2 EFHC1 EPDR1 ERBB2 EXOC3-AS1 FAM124B FAM222B FARS2 FAS FASLG FHL3 FOXD4L1 FRS3 GAD1 GATA1 GDPD5 GFI1B GLIS3 GNAI2 GNE GPS2 GSE1 HCK HLA-DPB1 HOXA1 HOXA9 HOXB9 HOXC8 HYKK IL16 ILF3 INCA1 IP6K3 IQCN ITGB4 KCTD9 KIF1A KIR2DL4 KLK15 KPRP KRTAP26-1 LMO2 LNX1 LPAR2 MAPKBP1 MEMO1 METTL17 MIEN1 MIIP MISP MSRB3 MVP NCK2 NEDD9 NEU4 NOL4L-DT NR1D2 NSMF NUP210 ODF1 OIP5 OTUB2 OTX1 PATZ1 PDGFRB PDLIM4 PER1 PIGS PIN1 PLEKHN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PTPN14 PXN RAD23A RANBP3L RERE RFX3 RHOA RHOQ RNF213 RNF214 SAXO1 SCAND1 SCRIB SETDB1 SHISA6 SIK3 SLC15A3 SLC25A6 SMAD1 SMG9 SNAI1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TBC1D22B TCAF1 TEKT4 TENT5C THRB TIE1 TLE5 TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TSGA10IP TSSK3 TTC23 TTLL10 TXN2 TXNDC5 USP2 VASN VCL WT1-AS YPEL3 ZBP1 ZIC1 ZNF541 ZNF580 ZNF581 ZNF688 ZNF785
Entrez ID		2571	7205
HPRD ID		12011	04242
Ensembl ID		ENSG00000128683	ENSG00000087077
Uniprot IDs		A0A0S2Z3V5 Q8IVA8 Q99259	Q15654
PDB IDs		2OKJ 3VP6	1X61 2DLO
Enriched GO Terms of Interacting Partners?
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