GAD1 and HAAO

Data Source:
HPRD (two hybrid)

		GAD1	HAAO
Description		glutamate decarboxylase 1	3-hydroxyanthranilate 3,4-dioxygenase
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GO Annotations	Cellular Component	Plasma Membrane Cell Cortex Vesicle Membrane Axon Terminus Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane	Cytoplasm Cytosol
	Molecular Function	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding Protein N-terminus Binding	3-hydroxyanthranilate 3,4-dioxygenase Activity Protein Binding Ferrous Iron Binding Electron Transfer Activity
	Biological Process	Glutamate Catabolic Process Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Gamma-aminobutyric Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Social Behavior Locomotory Exploration Behavior Neurotransmitter Biosynthetic Process Response To Drug	Tryptophan Catabolic Process NAD Biosynthetic Process Response To Zinc Ion Quinolinate Biosynthetic Process Electron Transport Chain 'de Novo' NAD Biosynthetic Process From Tryptophan Anthranilate Metabolic Process Response To Cadmium Ion Quinolinate Metabolic Process Neuron Cellular Homeostasis
Pathways		GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling	Tryptophan catabolism
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases		Cerebral palsy
GWAS		Menopause (age at onset) ( 26414677)	Birth weight ( 31043758) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Glucose homeostasis traits ( 25524916) Hypospadias ( 25108383) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 27841878 28739976) White matter hyperintensity burden ( 25663218)
Interacting Genes		15 interacting genes: AGTRAP CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE STK3 TRIM23 TRIP6	4 interacting genes: ARHGDIA GAD1 POT1 TERF2IP
Entrez ID		2571	23498
HPRD ID		12011	05158
Ensembl ID		ENSG00000128683	ENSG00000162882
Uniprot IDs		A0A0S2Z3V5 Q8IVA8 Q99259	P46952
PDB IDs		2OKJ 3VP6	2QNK 5TK5 5TKQ
Enriched GO Terms of Interacting Partners?
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