STK3 and SLMAP

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology)

		STK3	SLMAP
Description		serine/threonine kinase 3	sarcolemma associated protein
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Smooth Endoplasmic Reticulum Microtubule Organizing Center Integral Component Of Plasma Membrane Sarcolemma
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity
Pathways		Signaling by Hippo
Drugs		Fostamatinib
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 30578418) FEV1 ( 30804560) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Peak expiratory flow ( 30804560)
Interacting Genes		40 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MARK2 MBP MOB1B MOB3B MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 RASSF2 RASSF4 SAV1 SLMAP SNIP1 STK4 SULT2A1 TFPT TRAF1 ZC3H7A	1 interacting genes: STK3
Entrez ID		6788	7871
HPRD ID		05433	04079
Ensembl ID		ENSG00000104375	ENSG00000163681
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	B7Z6C7 B7Z964 Q14BN4
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2	6AKM 6AR0 6AR2
Enriched GO Terms of Interacting Partners?
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