STK3 and EIF4EBP1

Data Source:
BioGRID (enzymatic study)

		STK3	EIF4EBP1
Description		serine/threonine kinase 3	eukaryotic translation initiation factor 4E binding protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation
Pathways		Signaling by Hippo	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs		Fostamatinib
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Menopause (age at onset) ( 29773799)
Interacting Genes		40 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MARK2 MBP MOB1B MOB3B MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 RASSF2 RASSF4 SAV1 SLMAP SNIP1 STK4 SULT2A1 TFPT TRAF1 ZC3H7A	38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		6788	1978
HPRD ID		05433	03746
Ensembl ID		ENSG00000104375	ENSG00000187840
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	Q13541
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2	1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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