TMEM86B and VAMP3

Data Source:
BioGRID (two hybrid)

		TMEM86B	VAMP3
Description		transmembrane protein 86B	vesicle associated membrane protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Early Endosome Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Integral Component Of Synaptic Vesicle Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity Alkenylglycerophosphoethanolamine Hydrolase Activity	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding
	Biological Process	Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process	Positive Regulation Of Receptor Recycling Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Membrane Organization Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Interferon-gamma Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell
Pathways		Acyl chain remodelling of PC	ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Systemic lupus erythematosus ( 33536424 28714469)	Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)
Interacting Genes		105 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22	63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC16A2 SNAP23 SNAP29 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VAMP8 VEGFD VSIR
Entrez ID		255043	9341
HPRD ID		14540	04711
Ensembl ID		ENSG00000180089	ENSG00000049245
Uniprot IDs		Q8N661	Q15836 Q6FGG2
PDB IDs
Enriched GO Terms of Interacting Partners?
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