RNASEH1 and ASPH

Data Source:
BioGRID (two hybrid)

		RNASEH1	ASPH
Description		ribonuclease H1	aspartate beta-hydroxylase
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GO Annotations	Cellular Component	Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding RNA Binding RNA-DNA Hybrid Ribonuclease Activity Ribonuclease Activity Protein Binding	Peptide-aspartate Beta-dioxygenase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	RNA Catabolic Process DNA Replication, Removal Of RNA Primer RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Muscle Contraction Protein Phosphopantetheinylation Electron Transport Chain Ion Transmembrane Transport Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cardiac Conduction
Pathways			Stimuli-sensing channels Ion homeostasis
Drugs			Aspartic acid
Diseases
GWAS			Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		8 interacting genes: ASPH EMD FAM3C NCS1 NRM TM9SF1 TMEM11 TRIM63	71 interacting genes: AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LRPAP1 LTA NUCB2 OCIAD1 PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11A SMIM11B SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		246243	444
HPRD ID		04989	08996
Ensembl ID		ENSG00000171865	ENSG00000198363
Uniprot IDs		B3KUD4 E5KN15 O60930	B4DQ07 B7ZM96 Q12797
PDB IDs		2QK9 2QKB 2QKK 3BSU	5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9
Enriched GO Terms of Interacting Partners?
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