ABCA4 and CNGB1

Data Source:
HPRD (in vivo)

		ABCA4	CNGB1
Description		ATP binding cassette subfamily A member 4	cyclic nucleotide gated channel subunit beta 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane	Golgi Membrane Photoreceptor Outer Segment Plasma Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Terminal Bouton Ciliary Membrane Transmembrane Transporter Complex
	Molecular Function	Transporter Activity Lipid Transporter Activity ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity	Intracellular CAMP-activated Cation Channel Activity Intracellular CGMP-activated Cation Channel Activity Protein Binding Ligand-gated Ion Channel Activity CAMP Binding CGMP Binding Protein-containing Complex Binding
	Biological Process	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport	Retina Homeostasis Cation Transport Visual Perception Sensory Perception Of Smell Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Protein Localization To Organelle Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Regulation Of Cytosolic Calcium Ion Concentration Cation Transmembrane Transport
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)	Retinitis pigmentosa (RP)
GWAS		D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)	Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)
Interacting Genes		1 interacting genes: CNGB1	3 interacting genes: ABCA4 PNN PRPH2
Entrez ID		24	1258
HPRD ID		03408	07204
Ensembl ID		ENSG00000198691	ENSG00000070729
Uniprot IDs		P78363 Q6AI28	Q14028
PDB IDs
Enriched GO Terms of Interacting Partners?
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