CNGB1 and ABCA4

Data Source:
HPRD (in vivo)

		CNGB1	ABCA4
Description		cyclic nucleotide gated channel subunit beta 1	ATP binding cassette subfamily A member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Plasma Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Terminal Bouton Ciliary Membrane Transmembrane Transporter Complex	Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane
	Molecular Function	Intracellular CAMP-activated Cation Channel Activity Intracellular CGMP-activated Cation Channel Activity Protein Binding Ligand-gated Ion Channel Activity CAMP Binding CGMP Binding Protein-containing Complex Binding	Transporter Activity Lipid Transporter Activity ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity
	Biological Process	Retina Homeostasis Cation Transport Visual Perception Sensory Perception Of Smell Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Protein Localization To Organelle Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Regulation Of Cytosolic Calcium Ion Concentration Cation Transmembrane Transport	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport
Drugs
Diseases		Retinitis pigmentosa (RP)	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)
GWAS		Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)	D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ABCA4 PNN PRPH2	1 interacting genes: CNGB1
Entrez ID		1258	24
HPRD ID		07204	03408
Ensembl ID		ENSG00000070729	ENSG00000198691
Uniprot IDs		Q14028	P78363 Q6AI28
PDB IDs
Enriched GO Terms of Interacting Partners?
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