CNGB1 and PRPH2

Data Source:
HPRD (in vitro)

		CNGB1	PRPH2
Description		cyclic nucleotide gated channel subunit beta 1	peripherin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Plasma Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Terminal Bouton Ciliary Membrane Transmembrane Transporter Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Intracellular CAMP-activated Cation Channel Activity Intracellular CGMP-activated Cation Channel Activity Protein Binding Ligand-gated Ion Channel Activity CAMP Binding CGMP Binding Protein-containing Complex Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Retina Homeostasis Cation Transport Visual Perception Sensory Perception Of Smell Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Protein Localization To Organelle Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Regulation Of Cytosolic Calcium Ion Concentration Cation Transmembrane Transport	Cell Adhesion Visual Perception Photoreceptor Cell Outer Segment Organization Detection Of Light Stimulus Involved In Visual Perception Protein Homooligomerization Protein Heterooligomerization Retina Development In Camera-type Eye
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases		Retinitis pigmentosa (RP)	Vitelliform macular dystrophy, including: Best disease / Juvenile vitelliform macular dystrophy (VMD2) ; Adult-onset vitelliform macular dystrophy (AVMD) Retinitis pigmentosa (RP) Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)	Pulse pressure ( 27841878)
Interacting Genes		3 interacting genes: ABCA4 PNN PRPH2	4 interacting genes: CNGB1 GRAP2 PRPH ROM1
Entrez ID		1258	5961
HPRD ID		07204	01553
Ensembl ID		ENSG00000070729	ENSG00000112619
Uniprot IDs		Q14028	P23942
PDB IDs
Enriched GO Terms of Interacting Partners?
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