SH3BP4 and AMT

Data Source:
BioGRID (affinity chromatography technology)

		SH3BP4	AMT
Description		SH3 domain binding protein 4	aminomethyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Clathrin-coated Pit Clathrin-coated Vesicle Extracellular Exosome	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	GDP-dissociation Inhibitor Activity Protein Binding Small GTPase Binding Identical Protein Binding	Aminomethyltransferase Activity Transaminase Activity
	Biological Process	Endocytosis Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System
Pathways		Amino acids regulate mTORC1	Glycine degradation
Drugs			Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obstetric antiphospholipid syndrome ( 28424481) Orofacial clefts ( 22419666) Platelet count ( 32888494) Plateletcrit ( 32888494)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		22 interacting genes: C2orf73 CCT3 CEP78 CIZ1 DNAJA4 FKBP4 GAPDHS GIPC1 GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 TCP1 TTC1 TXNL1 YWHAE YWHAG ZBTB37	2 interacting genes: PDLIM4 VAC14
Entrez ID		23677	275
HPRD ID		09285	01997
Ensembl ID		ENSG00000130147	ENSG00000145020
Uniprot IDs		Q9P0V3	A0A024R2U7 P48728
PDB IDs			1WSR 1WSV
Enriched GO Terms of Interacting Partners?
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