AMT and PDLIM4

Data Source:
BioGRID (two hybrid)

		AMT	PDLIM4
Description		aminomethyltransferase	PDZ and LIM domain 4
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Stress Fiber Nucleus Cytoplasm Cytoskeleton Adherens Junction Z Disc Lamellipodium Early Endosome Membrane Early Endosome Lumen Filamentous Actin Recycling Endosome Lumen Dendritic Spine Postsynaptic Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane
	Molecular Function	Aminomethyltransferase Activity Transaminase Activity	Actin Binding Protein Binding Protein Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System	Heart Development Actin Cytoskeleton Organization Actin Cytoskeleton Reorganization Muscle Structure Development Excitatory Chemical Synaptic Transmission
Pathways		Glycine degradation
Drugs		Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Height ( 28552196) Inflammatory bowel disease ( 28067908 23128233) Mosquito bite size ( 28199695) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: PDLIM4 VAC14	8 interacting genes: ABCA1 AMT FAM222B PTPN13 RBPMS SDCBP TRIP6 ZNF408
Entrez ID		275	8572
HPRD ID		01997	04571
Ensembl ID		ENSG00000145020	ENSG00000131435
Uniprot IDs		A0A024R2U7 P48728	A0A0S2Z4N4 P50479
PDB IDs		1WSR 1WSV	2EEG 2V1W 4Q2O
Enriched GO Terms of Interacting Partners?
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