ZMYND8 and SPOP

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		ZMYND8	SPOP
Description		zinc finger MYND-type containing 8	speckle type BTB/POZ protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Dendritic Spine Dendritic Shaft	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Methylated Histone Binding Protein N-terminus Binding Repressing Transcription Factor Binding Lysine-acetylated Histone Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Dendritic Spine Maintenance	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'on' state
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Migraine ( 27182965) Parahippocampal gyrus volume ( 31530798) Platelet distribution width ( 32888494) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Prostate cancer ( 23535732)
Interacting Genes		14 interacting genes: ATN1 CSNK1E ERBB2 FHOD1 H3C1 MEOX2 PBXIP1 PRKCB RERE SPOP SUMO2 USP7 ZBTB7A ZFYVE9	66 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		23613	8405
HPRD ID		10166	16004
Ensembl ID		ENSG00000101040	ENSG00000121067
Uniprot IDs		A0A087WVZ6 A6H8Y8 Q2HXV5 Q569J9 Q9ULU4	O43791
PDB IDs		4COS 5B73 5MQ4 5Y1Z	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A
Enriched GO Terms of Interacting Partners?
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