DCAF8 and PRMT8

Data Source:
BioGRID (two hybrid)

		DCAF8	PRMT8
Description		DDB1 and CUL4 associated factor 8	protein arginine methyltransferase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Plasma Membrane Anchored Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Protein Methylation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Protein Homooligomerization
Pathways		Neddylation
Drugs
Diseases
GWAS		Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)	Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)
Interacting Genes		12 interacting genes: DDB1 GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBPMS SUV39H1 THAP1 TNS2 TRIM54	22 interacting genes: CARM1 CEP162 COIL DCAF8 EWSR1 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 SYNCRIP TNPO2 UBL5 VHL ZNF451
Entrez ID		50717	56341
HPRD ID		18300	11029
Ensembl ID		ENSG00000132716	ENSG00000111218
Uniprot IDs		B7Z8C9 Q5TAQ9	Q59GT2 Q9NR22
PDB IDs		3I8E	4X41 5DST
Enriched GO Terms of Interacting Partners?
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