ARHGEF12 and KLHL20

Data Source:
BioGRID (enzymatic study)

		ARHGEF12	KLHL20
Description		Rho guanine nucleotide exchange factor 12	kelch like family member 20
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein K33-linked Ubiquitination
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Feeling miserable ( 29500382)
Interacting Genes		17 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC	41 interacting genes: ACTA1 ARHGEF12 ATG9A BCL6 BEX1 BEX2 C1orf216 C20orf85 C21orf58 CEP126 CIDEC CLCNKA COL8A1 CORO7 CRK CRMP1 DUSP21 ECT2 ENKD1 EPAS1 ERG28 GBP2 HR IVNS1ABP KLHL38 LRIF1 LUC7L2 MTNR1A NEDD9 NTAQ1 PIN1 PML PRMT6 RANBP3 RECK SLC13A5 STK16 SUV39H1 TFAP2D TNPO2 USP20
Entrez ID		23365	27252
HPRD ID		09207	13918
Ensembl ID		ENSG00000196914	ENSG00000076321
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	Q9Y2M5
PDB IDs		1TXD 1X86 2OMJ 2OS6	5YQ4 6GY5
Enriched GO Terms of Interacting Partners?
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