ARHGEF12 and CUL3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ARHGEF12	CUL3
Description		Rho guanine nucleotide exchange factor 12	cullin 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Polar Microtubule Cytosol Plasma Membrane Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Sperm Flagellum Extracellular Exosome Mitotic Spindle
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Protein Autoubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 28991256 25056061 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		17 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC	78 interacting genes: ABTB1 ABTB2 ACLY APP ARHGEF12 BTBD1 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CLK1 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 ELOC FOLR1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD13 KCTD17 KCTD5 KCTD6 KCTD7 KCTD9 KEAP1 KLHL12 KLHL2 KLHL3 KLHL42 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDCD6 PDIA2 PEF1 RBBP8 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SPOP SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 UBE2R2 WNT7B ZMAT4
Entrez ID		23365	8452
HPRD ID		09207	09123
Ensembl ID		ENSG00000196914	ENSG00000036257
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	A0A024R475 B7Z600 Q13618
PDB IDs		1TXD 1X86 2OMJ 2OS6	2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M
Enriched GO Terms of Interacting Partners?
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