ARHGEF12 and PLXNB2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		ARHGEF12	PLXNB2
Description		Rho guanine nucleotide exchange factor 12	plexin B2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Semaphorin Receptor Complex Integral Component Of Plasma Membrane Cell Surface Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Semaphorin Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Neural Tube Closure Regulation Of Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Brain Development Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Excitatory Synapse Assembly Regulation Of Neuron Migration
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576 29875488) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)
Interacting Genes		17 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC	7 interacting genes: ARHGEF11 ARHGEF12 CENPU HMOX2 PFDN1 PTN RND1
Entrez ID		23365	23654
HPRD ID		09207	05050
Ensembl ID		ENSG00000196914	ENSG00000196576
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	O15031
PDB IDs		1TXD 1X86 2OMJ 2OS6	4E71
Enriched GO Terms of Interacting Partners?
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