KLHL20 and CLCNKA

Data Source:
BioGRID (two hybrid)

		KLHL20	CLCNKA
Description		kelch like family member 20	chloride voltage-gated channel Ka
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	Voltage-gated Chloride Channel Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein K33-linked Ubiquitination	Chloride Transport Excretion Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Stimuli-sensing channels
Drugs			Niflumic acid Talniflumate
Diseases			Bartter syndrome
GWAS		Feeling miserable ( 29500382)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		41 interacting genes: ACTA1 ARHGEF12 ATG9A BCL6 BEX1 BEX2 C1orf216 C20orf85 C21orf58 CEP126 CIDEC CLCNKA COL8A1 CORO7 CRK CRMP1 DUSP21 ECT2 ENKD1 EPAS1 ERG28 GBP2 HR IVNS1ABP KLHL38 LRIF1 LUC7L2 MTNR1A NEDD9 NTAQ1 PIN1 PML PRMT6 RANBP3 RECK SLC13A5 STK16 SUV39H1 TFAP2D TNPO2 USP20	22 interacting genes: C7orf31 CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511
Entrez ID		27252	1187
HPRD ID		13918	03608
Ensembl ID		ENSG00000076321	ENSG00000186510
Uniprot IDs		Q9Y2M5	P51800
PDB IDs		5YQ4 6GY5	2PFI
Enriched GO Terms of Interacting Partners?
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