ACSL6 and KLHL3

Data Source:
BioGRID (affinity chromatography technology)

		ACSL6	KLHL3
Description		acyl-CoA synthetase long chain family member 6	kelch like family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		3 interacting genes: PCMTD2 PHYH ZNF655	18 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK1 WNK3 WNK4
Entrez ID		23305	26249
HPRD ID		09190	09011
Ensembl ID		ENSG00000164398	ENSG00000146021
Uniprot IDs		B2RB13 B4DFW3 Q9UKU0	Q9UH77
PDB IDs			4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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