ACSL6 and PHYH

Data Source:
HPRD (in vitro)

		ACSL6	PHYH
Description		acyl-CoA synthetase long chain family member 6	phytanoyl-CoA 2-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol 9+0 Non-motile Cilium
	Molecular Function	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Protein Binding Ferrous Iron Binding Carboxylic Acid Binding L-ascorbic Acid Binding Phytanoyl-CoA Dioxygenase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs			Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa
Diseases			Refsum disease; Heredopathia atactica polyneuritiformis
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: PCMTD2 PHYH ZNF655	11 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PATJ PEX7 PHYHIP SIRPA TOM1L1
Entrez ID		23305	5264
HPRD ID		09190	03609
Ensembl ID		ENSG00000164398	ENSG00000107537
Uniprot IDs		B2RB13 B4DFW3 Q9UKU0	O14832
PDB IDs			2A1X
Enriched GO Terms of Interacting Partners?
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