MTUS2 and SNW1

Data Source:
BioGRID (two hybrid, two hybrid)

		MTUS2	SNW1
Description		microtubule associated scaffold protein 2	SNW domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytoplasmic Microtubule	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Microtubule Binding Protein Homodimerization Activity	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Enzyme Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding SMAD Binding Androgen Receptor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Viral Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation By Host Of Viral Transcription Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Positive Regulation Of Histone H3-K4 Methylation Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid
Pathways			Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Insomnia (caffeine-induced) ( 22754043) Obesity-related traits ( 23251661) Triptolide cytotoxicity ( 26121980)	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Interacting Genes		326 interacting genes: - ABHD15 ACSM1 AEN AFF4 AKT1 ANKRD11 ANKS1A AQP1 ARL4A ARNT2 AXIN1 BANF2 BARD1 BCL6 BEX2 BMP7 BYSL C19orf44 C1orf109 C1orf216 C1orf35 C21orf58 C2CD6 C8orf34 CACNB3 CATIP CATSPER1 CBX8 CCAR1 CCDC116 CCDC120 CCDC146 CCDC17 CCDC185 CCDC187 CCDC198 CCDC6 CCDC60 CCHCR1 CDC20B CDC5L CDC7 CDC73 CDK18 CDK5R1 CDKL3 CDKN1A CDKN1B CEP57L1 CEP95 CERK CHIC2 CNNM3 COG2 CREB5 CRY2 CSF1 CTSZ CWF19L2 CXCL11 CXCL16 CYSLTR2 DCDC2B DCTN4 DCX DDX6 DHRS1 DLGAP4 DLGAP5 DMRT3 DOCK2 DTNB EHHADH EIF3D ENKD1 ENPP7 EXOC8 FAM107A FAM110A FAM124B FAM13C FAM161A FAM161B FAM71E2 FAM74A4 FAM90A1 FASTKD5 FBXL18 FBXO34 FBXW5 FCHSD2 FHL3 FLYWCH1 FNDC11 GADD45GIP1 GAL3ST2 GAS2L2 GEM GGN GNL3L GOLGA2P11 GPKOW GRAP2 GSTP1 GTF2I GTPBP10 HAPLN2 HAUS1 HBZ HCK HDAC4 HOXB5 HOXB9 HSF2 ICAM4 IL16 INO80B IQCE ITGB4 ITGB5 ITSN1 JMY JOSD1 JRK KANK2 KAT5 KIF1A KIFC3 KRT6A KRT75 KRT76 LENG1 LIMS2 LINC00636 LMO2 LMO3 LMO4 LNX1 LRR1 LYSMD1 MAGEA8 MARK4 MBD3 METTL17 MFAP1 MOS MRPL11 MTMR6 MYO15B MYOM1 MYPOP NDEL1 NDOR1 NEFL NELFE NHSL2 NTAQ1 NUBPL NUDT10 NXF1 ODAD3 ODF1 PCDHB14 PDE4DIP PDZD4 PIBF1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 PLK4 PLSCR4 POLDIP2 POLDIP3 PPHLN1 PPP1R18 PRKAA1 PRKAA2 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PTCD1 PTK7 PTPMT1 RAB3IL1 RALY RANBP3L RAP1B RASAL3 RASD1 RBM41 RCOR3 RGS2 RHPN1 RIBC2 RNF6 ROBO3 RPA1 RPL9 RPS19BP1 RTP5 SAMD4A SCEL SCNM1 SDCBP SELENOM SETD5 SH2D4A SH3RF2 SHFL SLC22A5 SLC23A1 SLC25A42 SLC25A48 SLC25A6 SLIRP SMARCD1 SMARCE1 SMG9 SNAI1 SNHG11 SNRPA SNRPB2 SNW1 SPATA8 SPATC1L SPG21 SPG7 STK16 SYT6 TACO1 TAF13 TBC1D22B TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP7 TLE5 TNIP3 TNNI1 TP53RK TRIM29 TRIM42 TSGA10IP TSHZ3 TTC23 TTLL10 TULP2 TXN2 UBTFL1 USP2 USP22 UTP14C VASN WAC ZBTB16 ZBTB38 ZBTB47 ZC2HC1C ZFC3H1 ZFHX3 ZFP1 ZFP2 ZFP64 ZFYVE21 ZMAT2 ZMYND10 ZNF124 ZNF136 ZNF17 ZNF20 ZNF224 ZNF23 ZNF230 ZNF232 ZNF239 ZNF250 ZNF266 ZNF3 ZNF329 ZNF337 ZNF35 ZNF408 ZNF410 ZNF414 ZNF415 ZNF417 ZNF426 ZNF438 ZNF439 ZNF440 ZNF48 ZNF490 ZNF497 ZNF512B ZNF557 ZNF564 ZNF572 ZNF580 ZNF581 ZNF587 ZNF599 ZNF607 ZNF613 ZNF624 ZNF648 ZNF655 ZNF669 ZNF670 ZNF696 ZNF76 ZNF764 ZNF774 ZNF775 ZNF785 ZNF792 ZNF837 ZNF844 ZSCAN12 ZSCAN26	97 interacting genes: ABLIM3 ACTN2 ASCC2 BICD2 BYSL C1orf216 CCDC125 CEP55 CEP70 CIR1 CWF19L2 DAXX EP300 ERCC3 EXOSC5 FAM90A1 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OSTF1 PABPN1 PCBD2 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBL1 RBL2 RBPJ RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNRNP200 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 TNNT1 TOP1 TRAF1 TRIM15 TRIM23 TRIM55 TRIM63 TTC14 USF1 VAV2 VDR VPS39 WBP4 ZSCAN1
Entrez ID		23281	22938
HPRD ID		11108	04340
Ensembl ID		ENSG00000132938	ENSG00000100603
Uniprot IDs		Q5JR59	G3V3A4 Q13573
PDB IDs			5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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