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MTUS2 and NEFL
Data Source:
BioGRID
(two hybrid)
MTUS2
NEFL
Description
microtubule associated scaffold protein 2
neurofilament light
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Cytoplasmic Microtubule
Cytoplasm
Cytosol
Neurofilament
Axon
Growth Cone
Neuromuscular Junction
Schaffer Collateral - CA1 Synapse
Cholinergic Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Presynaptic Intermediate Filament Cytoskeleton
Axon Cytoplasm
Molecular Function
Protein Binding
Microtubule Binding
Protein Homodimerization Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Phospholipase Binding
Protein-containing Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Biological Process
MAPK Cascade
Microtubule Cytoskeleton Organization
Anterograde Axonal Transport
Retrograde Axonal Transport
Response To Toxic Substance
Peripheral Nervous System Axon Regeneration
Axonal Transport Of Mitochondrion
Spinal Cord Development
Hippocampus Development
Cerebral Cortex Development
Regulation Of Axon Diameter
Neurofilament Bundle Assembly
Locomotion
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Intermediate Filament Polymerization Or Depolymerization
Intermediate Filament Organization
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Neuromuscular Process Controlling Balance
Protein Polymerization
Response To Corticosterone
Neurofilament Cytoskeleton Organization
Synapse Maturation
Postsynaptic Intermediate Filament Cytoskeleton Organization
Response To Sodium Arsenite
Response To Acrylamide
Regulation Of NMDA Receptor Activity
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Insomnia (caffeine-induced) (
22754043
)
Obesity-related traits (
23251661
)
Triptolide cytotoxicity (
26121980
)
Fear of minor pain (
28701861
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) (
24554482
)
Interacting Genes
326 interacting genes:
-
ABHD15
ACSM1
AEN
AFF4
AKT1
ANKRD11
ANKS1A
AQP1
ARL4A
ARNT2
AXIN1
BANF2
BARD1
BCL6
BEX2
BMP7
BYSL
C19orf44
C1orf109
C1orf216
C1orf35
C21orf58
C2CD6
C8orf34
CACNB3
CATIP
CATSPER1
CBX8
CCAR1
CCDC116
CCDC120
CCDC146
CCDC17
CCDC185
CCDC187
CCDC198
CCDC6
CCDC60
CCHCR1
CDC20B
CDC5L
CDC7
CDC73
CDK18
CDK5R1
CDKL3
CDKN1A
CDKN1B
CEP57L1
CEP95
CERK
CHIC2
CNNM3
COG2
CREB5
CRY2
CSF1
CTSZ
CWF19L2
CXCL11
CXCL16
CYSLTR2
DCDC2B
DCTN4
DCX
DDX6
DHRS1
DLGAP4
DLGAP5
DMRT3
DOCK2
DTNB
EHHADH
EIF3D
ENKD1
ENPP7
EXOC8
FAM107A
FAM110A
FAM124B
FAM13C
FAM161A
FAM161B
FAM71E2
FAM74A4
FAM90A1
FASTKD5
FBXL18
FBXO34
FBXW5
FCHSD2
FHL3
FLYWCH1
FNDC11
GADD45GIP1
GAL3ST2
GAS2L2
GEM
GGN
GNL3L
GOLGA2P11
GPKOW
GRAP2
GSTP1
GTF2I
GTPBP10
HAPLN2
HAUS1
HBZ
HCK
HDAC4
HOXB5
HOXB9
HSF2
ICAM4
IL16
INO80B
IQCE
ITGB4
ITGB5
ITSN1
JMY
JOSD1
JRK
KANK2
KAT5
KIF1A
KIFC3
KRT6A
KRT75
KRT76
LENG1
LIMS2
LINC00636
LMO2
LMO3
LMO4
LNX1
LRR1
LYSMD1
MAGEA8
MARK4
MBD3
METTL17
MFAP1
MOS
MRPL11
MTMR6
MYO15B
MYOM1
MYPOP
NDEL1
NDOR1
NEFL
NELFE
NHSL2
NTAQ1
NUBPL
NUDT10
NXF1
ODAD3
ODF1
PCDHB14
PDE4DIP
PDZD4
PIBF1
PIN1
PKN1
PKN3
PKP2
PLEKHN1
PLK4
PLSCR4
POLDIP2
POLDIP3
PPHLN1
PPP1R18
PRKAA1
PRKAA2
PRPF18
PRPF31
PRR35
PSMA1
PSMB1
PTCD1
PTK7
PTPMT1
RAB3IL1
RALY
RANBP3L
RAP1B
RASAL3
RASD1
RBM41
RCOR3
RGS2
RHPN1
RIBC2
RNF6
ROBO3
RPA1
RPL9
RPS19BP1
RTP5
SAMD4A
SCEL
SCNM1
SDCBP
SELENOM
SETD5
SH2D4A
SH3RF2
SHFL
SLC22A5
SLC23A1
SLC25A42
SLC25A48
SLC25A6
SLIRP
SMARCD1
SMARCE1
SMG9
SNAI1
SNHG11
SNRPA
SNRPB2
SNW1
SPATA8
SPATC1L
SPG21
SPG7
STK16
SYT6
TACO1
TAF13
TBC1D22B
TCEA2
TCEANC
TCHP
TEAD4
TEPSIN
THAP7
TLE5
TNIP3
TNNI1
TP53RK
TRIM29
TRIM42
TSGA10IP
TSHZ3
TTC23
TTLL10
TULP2
TXN2
UBTFL1
USP2
USP22
UTP14C
VASN
WAC
ZBTB16
ZBTB38
ZBTB47
ZC2HC1C
ZFC3H1
ZFHX3
ZFP1
ZFP2
ZFP64
ZFYVE21
ZMAT2
ZMYND10
ZNF124
ZNF136
ZNF17
ZNF20
ZNF224
ZNF23
ZNF230
ZNF232
ZNF239
ZNF250
ZNF266
ZNF3
ZNF329
ZNF337
ZNF35
ZNF408
ZNF410
ZNF414
ZNF415
ZNF417
ZNF426
ZNF438
ZNF439
ZNF440
ZNF48
ZNF490
ZNF497
ZNF512B
ZNF557
ZNF564
ZNF572
ZNF580
ZNF581
ZNF587
ZNF599
ZNF607
ZNF613
ZNF624
ZNF648
ZNF655
ZNF669
ZNF670
ZNF696
ZNF76
ZNF764
ZNF774
ZNF775
ZNF785
ZNF792
ZNF837
ZNF844
ZSCAN12
ZSCAN26
50 interacting genes:
BRD7
CCDC13
CCDC172
CCDC33
CCNC
CDK5RAP2
CEP57L1
CHD3
DES
ENKD1
GFAP
GOLGA2
GORASP1
GRIN1
HGS
KDM1A
KIFC3
KLC3
KRT13
KRT15
KRT18
MAP2
MTMR2
MTUS2
MYO15B
MYO5A
NDN
NEFH
NEFM
NEK6
NME7
PDE4DIP
PIAS4
PKN1
PPP1R16B
PPP1R18
PRMT6
SKIL
SMYD1
SPTAN1
TERF1
TEX11
TRIM55
TRIM63
TSC1
TXLNB
USHBP1
USP2
VIM
YWHAG
Entrez ID
23281
4747
HPRD ID
11108
01206
Ensembl ID
ENSG00000132938
ENSG00000277586
Uniprot IDs
Q5JR59
P07196
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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